COVID-19 Vaccine Linked To Syndrome Causing Chronic Health Problems: Yale Study

A new study found that a group of people who received the COVID-19 vaccine suffer from chronic symptoms that developed soon after getting the jab, in what researchers now refer to as post-vaccination syndrome (PVS).

Researchers at Yale University have identified specific immune markers linked to post-vaccination syndrome. The Yale study, published on February 19, 2025, analyzed immune responses in hundreds of participants and found that a subset of individuals might be predisposed to heightened immune reactions following vaccination. This could explain the development of PVS.

The condition is seemingly driven by an overactive immune response in certain individuals. Normally, vaccines work by stimulating the immune system to recognize and fight the virus if exposed in the future. However, in rare cases, the immune system may remain in an activated state, leading to symptoms such as fatigue, muscle pain, and cognitive difficulties. These prolonged immune responses can cause inflammation and disrupt normal bodily functions, contributing to the persistence of symptoms.

According to the study, those suffering from the condition experience exercise intolerance, excessive fatigue, brain fog, dizziness, and insomnia. Symptoms can manifest about two days after getting vaxxed and persist over time.

"We’re only just starting to make headway in understanding PVS," explained Harlan Krumholz, Professor of Medicine at YSM and co-senior author of the study.

"Every medical intervention carries some risk, and it’s important to acknowledge that adverse events can occur with vaccines."

However, the researchers highlighted the need for more research to determine the exact systems causing these symptoms. While the majority of vaccinated individuals did not experience long-term effects, the team noted that understanding these cases is crucial for addressing public concerns and guiding future vaccination strategies.

"I want to emphasize that this is still a work in progress," Akiko Iwasaki, an immunologist and co-senior author of the study, told the New York Times.

Since the start of the pandemic in 2019, over 760 million COVID-19 cases and 6.9 million deaths have been reported globally, according to data from the World Health Organization (WHO). Vaccination efforts ramped up quickly, with approximately 13 billion doses administered worldwide by March 2023. In the United States alone, 672 million doses were administered. Thousands have also come forward saying the vaccinations have harmed them.

Researchers are hopeful that these findings will help develop targeted treatments and improve vaccine safety in the future.

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